Central Pontine Myelinolysis

A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6)

Also Known As:

Myelinolysis, Central Pontine; Extrapontine Myelinoclasis; Myelinoclasis, Central Pontine; Pontine Myelinolysis, Central; Central Pontine Myelinoclasis; Extrapontine Myelinoclases; Extrapontine Myelinolyses; Myelinoclases, Extrapontine; Myelinoclasis, Extrapontine; Myelinolyses, Extrapontine; Myelinolysis, Extrapontine; Extrapontine Myelinolysis

Nervous System Diseases: 14178
- Demyelinating Diseases: 9131
  - Central Pontine Myelinolysis: 253
- Central Nervous System Diseases: 4213
  - Brain Diseases: 15694
    - Metabolic Brain Diseases: 215
      - Central Pontine Myelinolysis: 253
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Metabolic Brain Diseases: 215
    - Central Pontine Myelinolysis: 253

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